Humanized Antibody

Progression and Direction of Humanized Antibody Research

人源化抗体研究历程及发展趋势

Humanized antibody has developed from chimeric antibody and reshaped antibody to the present fully human antibody .

人源化抗体的形式也从最初的嵌合抗体、改型抗体等逐步发展为今天的人抗体。

Research of Humanized Antibody Against Human Cytomegalovirus

抗巨细胞病毒人源化抗体的研究

Structure modeling of mouse McAb OKT3 combining sites and design of humanized antibody

鼠抗体OKT3结合位点的结构模拟和改形设计

Treatment of ulcerative colitis with a humanized antibody to the α _4 β _7 integrin

人工α4β7整合素抗体治疗溃疡性结肠炎

Inhibition of the Recurrence of Hepatitis B Virus after Liver Transplantation by Recombinant Adenoviral Vector Encoding Full Length Gene of Humanized Antibody

表面抗体基因在肝移植中抑制乙型肝炎病毒再感染的实验研究

Reforming of the heterogeneity of murine antibody has expressed human-mouse chimerical antibody , humanized antibody and gene library technology .

对抗体异源性的改造经历了人&鼠嵌合抗体、人源化抗体和基因文库技术使人型抗体的生产走向可能。

The expression of humanized antibody containing mutated Fc region ( hu12F6m ) was confirmed by ELISA and RT-PCR .

ELISA和RTPCR证实，恒定区特定位点突变的人源化抗体hu12F6m在CHO细胞中获得了表达。

Therapeutic mAbs has developed from reshaping antibody and humanized antibody to fully human antibody in order to lower supersensitivity resulting from mouse antibody .

为了降低鼠源抗体引起的超敏反应，治疗性单克隆抗体已由改型抗体，人源化抗体发展到全人抗体。

Conclusion The expression vector of humanized antibody light chain gene of against HCV is constructed effectively which laya solid foundation for further constructing the recombinant expression vector of humanized antibody Fab fragment against HCV .

结论人源性丙肝病毒抗体轻链基因表达载体是高效的，为下一步构建丙肝病毒抗体Fab段基因重组载体奠定了基础。

Advances in the Studies of Humanized Anti-platelet Antibody & Review

抗血小板人源化抗体的研究进展

Advances in humanized monoclonal antibody for therapeutic uses

治疗性人源化单克隆抗体研究进展

Construction and expression of humanized anti-EGFR antibody

新型抗EGFR人源化抗体基因的构建和表达

Expression , purification and functional identification of the humanized monoclonal antibody against ScFv of tetanuss toxin

人源抗破伤风毒素单链抗体（ScFv）的原核表达、纯化及功能鉴定

High Level Expression of Humanized Anti-keratin Antibody and Its Effect on Cultured Keratinocytes Preliminary Study on the Relationship between Psoriasis and the Apoptosis of Keratinocytes

人源性抗角蛋白抗体的高效表达及其作用研究银屑病与角朊细胞凋亡关系初探

Construction and Expression of a Recombinant Antibody targeted Plasminogen Activator Composed of a Humanized Monoclonal Antibody Against Activated Human Platelets and a Single chain Urokinase

重组抗体-尿激酶导向溶栓剂的基因构建及表达

We must prove that there is really brain glioma antibody in the blood of patients , then we can establish the base for constructing humanized phage antibody library .

为了构建人源性抗脑胶质瘤抗体库，我们必须先从患者的血液内检测到抗脑胶质瘤抗体，才能为建立人源性噬菌体抗体库奠定基础。

Measurement of Affinity Constant of Humanized Monoclonal Antibody 813-F ( ab ) _2 Binding to Platelets of Human , Macaque and Dog

人源化单抗813-F（ab）2与人、猕猴、毕格犬血小板反应亲和常数的测定

CONCLUSION : By guided-selection and chain shuffling technique , the humanized Fab antibody against HAb18G is obtained , which lays the foundation for further research .

结论：利用导向选择链更替技术，筛选出特异性较强、完全人源化的抗肝癌抗原HAb18G的Fab抗体，为进一步的工作打下了基础。

Gene Sequence Panning of High and Special Affinity of Humanized Single-Chain Antibody Against Human Bladder Carcinoma Analysis of human leucocyte antigen allele and haplotype in 36 cases receiving living-related donor kidney transplantation

高亲和力抗膀胱癌单链抗体筛选及亲和力测定亲属活体肾移植人类白细胞抗原基因和单型分析36例

The important role of platelet in bleeding and thrombotic diseases , the present status of development on study of humanized anti-platelet antibody and its application in treatment of bleeding and thrombotic diseases were summarized in this review .

本文就血小板在出血和血栓性疾病中的作用，人源化抗体的发展现状和抗血小板人源化抗体在出血性及血栓性疾病中的应用作一综述。

We here will give a brief description of the development of phage antibody library in producing humanized monoclonal antibody and improving antibody performance , as well as of the challenges it faced and application prospected in the future .

本文就噬菌体抗体库技术在制备人源化单克隆抗体、改良抗体性能以及面临的挑战和应用前景等方面进行简要综述。

Conclusion Phage display library of humanized anti-HV antibody VH gene was constructed successfully , and recombinant phage clones with HV-binding activity were screened , thus laying the foundation for preparation of humanized anti-HV mAb .

结论成功地构建了人抗HV抗体VH基因噬菌体表面展示文库，并筛选到有HV结合活性的重组噬菌体克隆，为制备人源性抗HVmAb奠定了基础。

In addition to traditional photochemotherapy , radiotherapy , chemotherapy , and extracorporeal photochemotherapy , immunomodulators , such as tretinoins , interferons , interleukin-2 fusion protein , recombinant interleukin 12 and humanized monoclonal antibody may have a good therapeutic effect on the treatment of early stage mycosis fungoides .

除传统的光化学疗法、放疗、化疗、体外光化学疗法外，维A酸类、干扰素、白介素2融合蛋白、重组白介素12、人源化单克隆抗体等免疫调节剂对早期蕈样肉芽肿有较好的疗效。

Nowadays humanized anti-IL-8 monoclonal antibody has been used in clinical studies on related diseases .

人源化的抗IL-8单克隆抗体已经应用于相关疾病的临床研究中。

Epratuzumab is a humanized anti-CD22 monoclonal antibody .

epratuzumab是抗CD22的人源化单克隆抗体。

Effects of Humanized Recombinant CD25 Monoclonal Antibody on Activation and Proliferation of T Lymphocytes

人源化CD25单克隆抗体对外周血T淋巴细胞活化和增殖的影响

Construction and preliminary identification of humanized Fab fragment phage antibody library against Schistosoma japonica

人源性抗日本血吸虫噬菌体抗体库的构建及初步鉴定

Preparation and characterization of a humanized anti-human CD20 monoclonal antibody

抗CD20人源化抗体的制备及生物学活性鉴定